Ca Oscillations
This example is a Modelica version of the model presented in A
Minimal Generic Model of Bacteria-Induced Intracellular
Ca2+ Oscillations in Epithelial Cells by Camilla
Oxhamre, Agneta Richter-Dahlfors, Vladimir P. Zhdanov, and Bengt
Kasemoy. (Biophysical Journal Volume 88 April 2005 2976-2981)
Abstract
The toxin &alpha-hemolysin expressed by uropathogenic
Escherichia coli bacteria was recently shown as the first
pathophysiologically relevant protein to induce oscillations of the
intracellular Ca2+ concentration in target cells. Here,
we propose a generic three-variable kinetic model describing the
Ca2+ oscillations induced in single rat renal epithelial
cells by this toxin. Specifically, we take into account the
interplay between 1), the cytosolic Ca2+ concentration;
2), IP3-sensitive Ca2+ channels located in
the membrane separating the cytosol and endoplasmic reticulum; and
3), toxin-related activation of production of IP3 by
phospholipase C. With these ingredients, the predicted response of
cells exposed to the toxin is in good agreement with the results of
experiments.
Simulations
The simulation results are shown in the Figure
1. This plot corresponds to Fig 1C of the paper (Oxhamre
2005).
Contents
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