.Pharmacolibrary.Drugs.ATC.A.A04AD01

Information

Scopolamine (also known as hyoscine) is a tropane alkaloid with antimuscarinic properties, primarily used to prevent nausea and vomiting associated with motion sickness and postoperative recovery. It is FDA-approved and commonly administered as a transdermal patch or parenterally.

Pharmacokinetics

Pharmacokinetic parameters reported from healthy adult volunteers, after intravenous (IV) administration.

References

1. Alvarez-Jimenez, R, et al., & Stevens, J (2016). Model-based exposure-response analysis to quantify age related differences in the response to scopolamine in healthy subjects. British journal of clinical pharmacology 82(4) 1011–1021. DOI:10.1111/bcp.13031 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27273555

2. Hudson, RJ, et al., & Peterson, MD (2001). Pharmacokinetics of sufentanil in patients undergoing coronary artery bypass graft surgery. Journal of cardiothoracic and vascular anesthesia 15(6) 693–699. DOI:10.1053/jcan.2001.28311 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11748515

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)