.Pharmacolibrary.Drugs.ATC.A.A04AD01_1

Information

name: Scopolamine_1
ATC code: A04AD01_1
route: transdermal
compartments: 2
dosage: 1.5 mg
volume of distribution: 5.0 L
clearance: 1.4 L/h/kg
other parameters in model implementation

Scopolamine (also known as hyoscine) is a tropane alkaloid with antimuscarinic properties, primarily used to prevent nausea and vomiting associated with motion sickness and postoperative recovery. It is FDA-approved and commonly administered as a transdermal patch or parenterally.

Pharmacokinetics

Pharmacokinetic parameters following transdermal administration (scopolamine patch) in healthy adult volunteers.

References

  1. Delgado-Charro, MB, & Guy, RH (2014). Effective use of transdermal drug delivery in children. Advanced drug delivery reviews 73 63–82. DOI:10.1016/j.addr.2013.11.014 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24333231

  2. Berner, B, & John, VA (1994). Pharmacokinetic characterisation of transdermal delivery systems. Clinical pharmacokinetics 26(2) 121–134. DOI:10.2165/00003088-199426020-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8162656

  3. Guay, DR (2003). Clinical pharmacokinetics of drugs used to treat urge incontinence. Clinical pharmacokinetics 42(14) 1243–1285. DOI:10.2165/00003088-200342140-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14606931

Revisions

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