.Pharmacolibrary.Drugs.ATC.A.A06AH02 .Pharmacolibrary.Drugs.ATC.A.A06AH02| name: | Alvimopan | |
| ATC code: | A06AH02 | |
| route: | oral | |
| compartments: | 2 | |
| dosage: | 12 | mg |
| volume of distribution: | 30.2 | L |
| clearance: | 15.6 | L/h |
| other parameters in model implementation | ||
Alvimopan is a peripherally acting µ-opioid receptor antagonist used to accelerate the recovery of bowel function after bowel resection surgery. The drug reduces opioid-induced gastrointestinal side effects. It is approved for short-term inpatient use in adults undergoing bowel resection surgery.
Pharmacokinetic parameters are reported for healthy adult subjects after a single oral dose.
Foss, JF, et al., & Schmith, VD (2008). Pharmacokinetics of alvimopan and its metabolite in healthy volunteers and patients in postoperative ileus trials. Clinical pharmacology and therapeutics 83(5) 770–776. DOI:10.1038/sj.clpt.6100292 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17653140