.Pharmacolibrary.Drugs.ATC.A.A10BA02_1

Information

name:	Metformin_1
ATC code:	A10BA02_1
route:	oral
compartments:	2
dosage:	850	mg
volume of distribution:	65	L
clearance:	9	L/h
other parameters in model implementation

Metformin is an oral antihyperglycemic of the biguanide class, used in the treatment of type 2 diabetes mellitus; it is still widely used and approved as first-line therapy.

Pharmacokinetics

Pharmacokinetic parameters in patients with renal impairment compared to healthy subjects.

References

Graham, GG, et al., & Williams, KM (2011). Clinical pharmacokinetics of metformin. Clinical pharmacokinetics 50(2) 81–98. DOI:10.2165/11534750-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21241070
Scheen, AJ (1996). Clinical pharmacokinetics of metformin. Clinical pharmacokinetics 30(5) 359–371. DOI:10.2165/00003088-199630050-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8743335
Dhillon, S (2019). Dapagliflozin: A Review in Type 2 Diabetes. Drugs 79(10) 1135–1146. DOI:10.1007/s40265-019-01148-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31236801

Revisions

06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)

Generated at 2026-04-15T18:18:36Z by OpenModelicaOpenModelica 1.26.3 using GenerateDoc.mos