.Pharmacolibrary.Drugs.ATC.A.A10BD28 .Pharmacolibrary.Drugs.ATC.A.A10BD28| name: | MetforminAndTeneligliptin | |
| ATC code: | A10BD28 | |
| route: | oral | |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 60 | L |
| clearance: | 75 | L/h |
| other parameters in model implementation | ||
Metformin and teneligliptin is a fixed dose combination of two antidiabetic agents: metformin, a biguanide that reduces hepatic glucose production and increases insulin sensitivity, and teneligliptin, a DPP-4 inhibitor that increases incretin levels and glucose-dependent insulin secretion. This combination is approved and widely used for the treatment of type 2 diabetes mellitus in adults to improve glycemic control.
Estimated pharmacokinetic parameters for typical adult population receiving the fixed-dose combination orally. No primary published population pharmacokinetic (PopPK) models for the combination product found; parameters are based on known monotherapy PK data and fixed dose combination prescribing information.