.Pharmacolibrary.Drugs.ATC.C.C09BA04 .Pharmacolibrary.Drugs.ATC.C.C09BA04| name: | PerindoprilAndDiuretics | |
| ATC code: | C09BA04 | |
| route: | oral | |
| compartments: | 1 | |
| dosage: | 4 | mg |
| volume of distribution: | 0.8 | L |
| clearance: | 80 | mL/min |
| other parameters in model implementation | ||
Perindopril and diuretics (such as indapamide) is a fixed-dose combination therapy used primarily for the treatment of hypertension and heart failure. Perindopril is an angiotensin-converting enzyme (ACE) inhibitor that acts to lower blood pressure by inhibiting the renin-angiotensin-aldosterone system, while the diuretic component increases urinary excretion of sodium and water, further reducing blood pressure. This combination therapy is approved and widely used in current clinical practice.
Typical pharmacokinetic parameters for perindopril and indapamide combination in healthy adult subjects; parameters are estimated from publicly available sources for perindopril in combination with a thiazide-like diuretic (e.g., indapamide) as limited data for the fixed-dose combination are available.