.Pharmacolibrary.Drugs.ATC.C.C09DB06 .Pharmacolibrary.Drugs.ATC.C.C09DB06| name: | LosartanAndAmlodipine | |
| ATC code: | C09DB06 | |
| route: | oral | |
| compartments: | 2 | |
| dosage: | 50 | mg |
| volume of distribution: | 34 | L |
| clearance: | 34 | L/h |
| other parameters in model implementation | ||
Losartan and amlodipine is a fixed-dose combination drug used for the treatment of hypertension. Losartan is an angiotensin II receptor blocker (ARB) that relaxes blood vessels, while amlodipine is a calcium channel blocker that also dilates blood vessels. This combination is approved and commonly used today for patients whose blood pressure is not adequately controlled by either drug alone.
Estimated pharmacokinetic parameters for losartan and amlodipine fixed-dose combination in healthy adults. No dedicated population pharmacokinetic studies for the combination product were found; parameters are approximated based on published data for individual drugs.