.Pharmacolibrary.Drugs.ATC.D.D03AX05 .Pharmacolibrary.Drugs.ATC.D.D03AX05| name: | HyaluronicAcid | |
| ATC code: | D03AX05 | |
| route: | intravenous | |
| compartments: | 1 | |
| dosage: | 80 | mg |
| volume of distribution: | 0.23 | L |
| clearance: | 0.03 | L/kg/min |
| other parameters in model implementation | ||
Hyaluronic acid is a naturally occurring glycosaminoglycan distributed in connective, epithelial, and neural tissues. It is used medically as a topical wound healer, intra-articularly for osteoarthritis, and dermally as a cosmetic filler. It is considered safe and is widely used for wound healing and lubrication.
No peer-reviewed pharmacokinetic studies reporting classic PK parameters in humans for systemic administration. Hyaluronic acid pharmacokinetics is influenced by its molecular weight, formulation, and administration route. For topical and intra-articular use, systemic absorption is minimal; for intravenous administration (studied mostly experimentally), some parameters have been estimated.
Hahn, RG, et al., & Björne, H (2019). Fluid volume kinetics of 20% albumin. British journal of clinical pharmacology 85(6) 1303–1311. DOI:10.1111/bcp.13897 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30756411
Levitskaia, TG, et al., & Thrall, KD (2010). Biomaterials for the decorporation of (85)Sr in the rat. Health physics 99(3) 394–400. DOI:10.1097/HP.0b013e3181c4717d PUBMED:https://pubmed.ncbi.nlm.nih.gov/20699703