.Pharmacolibrary.Drugs.ATC.D.D10AD53 .Pharmacolibrary.Drugs.ATC.D.D10AD53| name: | AdapaleneCombinations | |
| ATC code: | D10AD53 | |
| route: | topical | |
| compartments: | 1 | |
| dosage: | 2 | mg |
| volume of distribution: | 5 | L |
| clearance: | 0.1 | L/h/kg |
| other parameters in model implementation | ||
Adapalene, in combination with benzoyl peroxide (as in ATC code D10AD53), is a topical retinoid used primarily for the treatment of acne vulgaris. The combination enhances comedolytic, anti-inflammatory, and antibacterial effects. This product is approved for clinical use in several countries.
Estimated pharmacokinetic model for healthy adults using topical gel formulation of adapalene 0.1% with benzoyl peroxide 2.5%; limited systemic absorption expected in healthy skin.