.Pharmacolibrary.Drugs.ATC.G.G03AC09 .Pharmacolibrary.Drugs.ATC.G.G03AC09| name: | Desogestrel | |
| ATC code: | G03AC09 | |
| route: | oral | |
| compartments: | 1 | |
| dosage: | 0.075 | mg |
| volume of distribution: | 4.3 | L |
| clearance: | 10.8 | L/h |
| other parameters in model implementation | ||
Desogestrel is a synthetic progestogen (progestin) used mainly as a hormonal contraceptive in oral tablets, either alone or combined with ethinyl estradiol. It is a third-generation progestin and is currently approved for use in many countries for female contraception.
Pharmacokinetic parameters reported for healthy adult women (aged 18-35), receiving an oral dose of desogestrel as part of contraceptive regimen.
Ginstman, C, et al., & Brynhildsen, J (2019). Plasma concentrations of etonogestrel in women using oral desogestrel before and after Roux-en-Y gastric bypass surgery: a pharmacokinetic study. BJOG : an international journal of obstetrics and gynaecology 126(4) 486–492. DOI:10.1111/1471-0528.15511 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30347490
Bergink, W, et al., & Qvist, I (1990). Serum pharmacokinetics of orally administered desogestrel and binding of contraceptive progestogens to sex hormone-binding globulin. American journal of obstetrics and gynecology 163(6 Pt 2) 2132–2137. DOI:10.1016/0002-9378(90)90553-j PUBMED:https://pubmed.ncbi.nlm.nih.gov/2147817