.Pharmacolibrary.Drugs.ATC.J.J01CF02

Information

name: Cloxacillin
ATC code: J01CF02
route: intravenous
compartments: 1
dosage: 500 mg
volume of distribution: 11.7 L
clearance: 7.12 L/h
other parameters in model implementation

Cloxacillin is a beta-lactam antibiotic of the penicillinase-resistant penicillin class. It is mainly used for the treatment of infections caused by penicillinase-producing staphylococci, particularly skin, respiratory tract, bone, and joint infections. Cloxacillin is approved for clinical use and remains a recommended choice for staphylococcal infections in many guidelines.

Pharmacokinetics

Pharmacokinetic parameters of cloxacillin reported in healthy adult volunteers (mixed sexes).

References

  1. Courjon, J, et al., & Goutelle, S (2020). A Population Pharmacokinetic Analysis of Continuous Infusion of Cloxacillin during . Antimicrobial agents and chemotherapy 64(12) –. DOI:10.1128/AAC.01562-20 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32988822

  2. James, ME, et al., & Sasi, P (2024). Gentamicin concentration and acute kidney injury in term neonates treated for neonatal sepsis with gentamicin and ampicillin-cloxacillin combination. Antimicrobial agents and chemotherapy 68(6) e0149523–None. DOI:10.1128/aac.01495-23 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38747600

Revisions


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