.Pharmacolibrary.Drugs.ATC.J.J01EB04

Information

Sulfapyridine is a sulfonamide antibacterial drug that was historically used to treat bacterial infections, particularly in the pre-penicillin era. It is a synthetic antimicrobial agent. Its use has largely declined due to the development of more effective and less toxic antibiotics, though it is sometimes still encountered as a metabolite of sulfasalazine, a drug used for rheumatoid arthritis and inflammatory bowel disease.

Pharmacokinetics

Pharmacokinetic parameters are reported for healthy adult volunteers following oral administration.

References

1. Ma, JJ, et al., & Yao, X (2009). Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population. Clinica chimica acta; international journal of clinical chemistry 407(1-2) 30–35. DOI:10.1016/j.cca.2009.06.025 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19560446

2. Kuhn, UD, et al., & Blume, HH (2010). Phenotyping with sulfasalazine - time dependence and relation to NAT2 pharmacogenetics. International journal of clinical pharmacology and therapeutics 48(1) 1–10. DOI:10.5414/cpp48001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20040334

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)