.Pharmacolibrary.Drugs.ATC.J.J05AR20 .Pharmacolibrary.Drugs.ATC.J.J05AR20| name: | EmtricitabineTenofovirAlafenamideAndBictegravir | |
| ATC code: | J05AR20 | |
| route: | oral | |
| compartments: | 1 | |
| dosage: | 200 | mg |
| volume of distribution: | 86 | L |
| clearance: | 7.17 | L/h |
| other parameters in model implementation | ||
Emtricitabine, tenofovir alafenamide, and bictegravir is a fixed-dose combination antiretroviral medication used in the treatment of HIV-1 infection in adults and pediatric patients. It acts by inhibiting viral reverse transcriptase (emtricitabine, tenofovir) and integrase (bictegravir), preventing the replication of HIV-1. The combination is approved and widely used today.
Mean pharmacokinetic parameters reported for healthy HIV-negative adult subjects receiving the fixed-dose combination as a single oral tablet once daily under fasting conditions.
Bruzzesi, E, et al., & Castagna, A (2024). Pharmacokinetic evaluation of bictegravir + emtricitabine + tenofovir alafenamide in HIV treatment. Expert opinion on drug metabolism & toxicology None 1–8. DOI:10.1080/17425255.2024.2428820 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39530796