.Pharmacolibrary.Drugs.ATC.M.M03CA01_1 .Pharmacolibrary.Drugs.ATC.M.M03CA01_1| name: | Dantrolene_1 | |
| ATC code: | M03CA01_1 | |
| route: | intravenous | |
| compartments: | 2 | |
| dosage: | 2.5 | mg |
| volume of distribution: | 0.53 | L |
| clearance: | 0.99 | mL/min/kg |
| other parameters in model implementation | ||
Dantrolene is a muscle relaxant used to treat malignant hyperthermia and spasticity. It acts by inhibiting Ca2+ release in skeletal muscle. It is approved and still used in clinical practice.
Pharmacokinetic parameters reported after intravenous administration in adult patients.
Bateman, RM, et al., & Prandi, E (2016). 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. Critical care (London, England) 20(Suppl 2) 94–None. DOI:10.1186/s13054-016-1208-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27885969