.Pharmacolibrary.Drugs.ATC.M.M09AX11 .Pharmacolibrary.Drugs.ATC.M.M09AX11| name: | Palovarotene | |
| ATC code: | M09AX11 | |
| route: | oral | |
| compartments: | 2 | |
| dosage: | 10 | mg |
| volume of distribution: | 282 | L |
| clearance: | 13.6 | L/h |
| other parameters in model implementation | ||
Palovarotene is a selective retinoic acid receptor gamma (RARγ) agonist developed for the treatment of fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder involving heterotopic ossification. As of 2023, palovarotene is approved in some regions for FOP and used under clinical investigation in others.
Pharmacokinetic parameters reported in healthy adult volunteers after oral administration of single and multiple doses.