.Pharmacolibrary.Drugs.ATC.N.N01AX05_1 .Pharmacolibrary.Drugs.ATC.N.N01AX05_1| name: | Alfaxalone_1 | |
| ATC code: | N01AX05_1 | |
| route: | intravenous | |
| compartments: | 2 | |
| dosage: | 2 | mg |
| volume of distribution: | 0.99 | L |
| clearance: | 23.7 | ml/min/kg |
| other parameters in model implementation | ||
Alfaxalone is a neuroactive steroid anesthetic agent, used for induction and maintenance of anesthesia primarily in veterinary medicine for dogs and cats; not approved for human use. It potentiates the effects of GABA at GABA-A receptors.
Pharmacokinetics in healthy adult beagle dogs after single intravenous bolus injection of 2 mg/kg.
Pypendop, BH, et al., & Pasloske, K (2018). Pharmacokinetics of alfaxalone infusions, context-sensitive half-time and recovery times in male neutered cats. Veterinary anaesthesia and analgesia 45(5) 630–639. DOI:10.1016/j.vaa.2018.06.003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30057008
Pypendop, BH, et al., & Pasloske, K (2018). Effective plasma alfaxalone concentration to produce immobility in male neutered cats. Veterinary anaesthesia and analgesia 45(3) 269–277. DOI:10.1016/j.vaa.2017.10.006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29415861