.Pharmacolibrary.Drugs.ATC.N.N02AJ23 .Pharmacolibrary.Drugs.ATC.N.N02AJ23| name: | HydrocodoneAndIbuprofen | |
| ATC code: | N02AJ23 | |
| route: | oral | |
| compartments: | 1 | |
| dosage: | 7.5 | mg |
| volume of distribution: | 12 | L |
| clearance: | 1.8 | L/h |
| other parameters in model implementation | ||
Hydrocodone and ibuprofen is a combination drug used to treat moderate to severe pain where treatment with an opioid is appropriate and for which alternative treatments are inadequate. Hydrocodone is a semi-synthetic opioid analgesic, and ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). The fixed combination is approved for short-term management of acute pain in adults. Hydrocodone acts as a mu-opioid receptor agonist, and ibuprofen acts by inhibiting prostaglandin synthesis via non-selective cyclooxygenase (COX) inhibition.
Pharmacokinetics after single oral administration of a fixed-dose combination (hydrocodone 7.5 mg/ibuprofen 200 mg) in healthy adults.
Thigpen, JC, et al., & Harirforoosh, S (2019). Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children. European journal of drug metabolism and pharmacokinetics 44(5) 591–609. DOI:10.1007/s13318-019-00552-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31006834