.Pharmacolibrary.Drugs.ATC.N.N05AH53 .Pharmacolibrary.Drugs.ATC.N.N05AH53| name: | OlanzapineAndSamidorphan | |
| ATC code: | N05AH53 | |
| route: | oral | |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 1000 | L |
| clearance: | 25 | L/h |
| other parameters in model implementation | ||
Olanzapine and samidorphan is a fixed-dose combination drug consisting of olanzapine, an atypical antipsychotic used for the treatment of schizophrenia and bipolar I disorder, and samidorphan, an opioid receptor antagonist used to mitigate olanzapine-induced weight gain. The combination (marketed as Lybalvi) is approved for use in adults.
Pharmacokinetic parameters derived from healthy adult subjects after oral administration of olanzapine and samidorphan combination; values approximated from published prescribing information.