.Pharmacolibrary.Drugs.ATC.N.N07AA01

Information

name: Neostigmine
ATC code: N07AA01
route: intravenous
compartments: 2
dosage: 2.5 mg
volume of distribution: 0.13 L
clearance: 1.1 mL/min/kg
other parameters in model implementation

Neostigmine is a reversible acetylcholinesterase inhibitor, used primarily in the management of myasthenia gravis, reversal of non-depolarizing neuromuscular blockade after surgery, and treatment of postoperative abdominal distention and urinary retention. It is an approved and widely used medication today.

Pharmacokinetics

Pharmacokinetic data reported for adult surgical patients receiving intravenous neostigmine for neuromuscular blockade reversal.

References

  1. Keating, GM (2016). Sugammadex: A Review of Neuromuscular Blockade Reversal. Drugs 76(10) 1041–1052. DOI:10.1007/s40265-016-0604-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27324403

  2. Onrust, SV, & Foster, RH (1999). Rapacuronium bromide: a review of its use in anaesthetic practice. Drugs 58(5) 887–918. DOI:10.2165/00003495-199958050-00011 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10595867

Revisions


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