.Pharmacolibrary.Drugs.ATC.R.R01AX30 .Pharmacolibrary.Drugs.ATC.R.R01AX30| name: | XylometazolineAndDexamethasone | |
| ATC code: | R01AX30 | |
| route: | intranasal | |
| compartments: | 1 | |
| dosage: | 0.14 | mg |
| volume of distribution: | 20 | L |
| clearance: | 12 | L/h |
| other parameters in model implementation | ||
The combination of xylometazoline, a topical nasal decongestant (alpha-adrenergic agonist), and dexamethasone, a corticosteroid with anti-inflammatory properties, is used in intranasal preparations to reduce nasal congestion and inflammation associated with rhinitis or sinusitis. It is not widely approved as a fixed drug combination in major markets, but is referenced under ATC code R01AX30.
No direct pharmacokinetic (PK) studies on the combination product exist. Estimates are based on published data of each substance administered intranasally in healthy adults.