.Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A07D_Antipropulsives.A07DA01_Diphenoxylate.Diphenoxylate .Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A07D_Antipropulsives.A07DA01_Diphenoxylate.Diphenoxylate| name: | Diphenoxylate | |
| ATC code: | A07DA01 | |
| route: | oral | |
| compartments: | 1 | |
| dosage: | 5 | mg |
| volume of distribution: | 3 | L |
| clearance: | 200 | mL/min |
| other parameters in model implementation | ||
Diphenoxylate is a synthetic opioid primarily used in combination with atropine to treat diarrhea. It acts mainly by slowing intestinal motility. It is approved for short-term management of acute diarrhea and is not recommended for pediatric use due to risks of respiratory depression.
Estimated pharmacokinetic parameters based on general pharmacological references and closely related opioid antidiarrheals; no comprehensive population PK study for diphenoxylate found in published literature.