.Pharmacolibrary.Drugs.B_BloodAndBloodFormingOrgans.B02B_VitaminKAndOtherHemostatics.B02BD07_CoagulationFactorXiii.CoagulationFactorXiii .Pharmacolibrary.Drugs.B_BloodAndBloodFormingOrgans.B02B_VitaminKAndOtherHemostatics.B02BD07_CoagulationFactorXiii.CoagulationFactorXiii| name: | CoagulationFactorXiii | |
| ATC code: | B02BD07 | |
| route: | intravenous | |
| compartments: | 1 | |
| dosage: | 35 | mg |
| volume of distribution: | 43.7 | L |
| clearance: | 0.243 | mL/h/kg |
| other parameters in model implementation | ||
Coagulation factor XIII is a clotting factor essential for the final steps of the coagulation cascade by crosslinking fibrin. It is used as a replacement therapy in patients with factor XIII deficiency, a rare bleeding disorder. Factor XIII concentrates are approved for use today to treat and prevent bleeding in individuals with congenital factor XIII deficiency.
Pharmacokinetic parameters reported in healthy adult subjects (mean age ~29 years, both sexes) following intravenous administration of recombinant factor XIII.