.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G04C_DrugsUsedInBenignProstaticHypertrophy.G04CA52_TamsulosinAndDutasteride.TamsulosinAndDutasteride .Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G04C_DrugsUsedInBenignProstaticHypertrophy.G04CA52_TamsulosinAndDutasteride.TamsulosinAndDutasteride| name: | TamsulosinAndDutasteride | |
| ATC code: | G04CA52 | |
| route: | oral | |
| compartments: | 2 | |
| dosage: | 0.4 | mg |
| volume of distribution: | 16 | L |
| clearance: | 9.2 | L/h |
| other parameters in model implementation | ||
Tamsulosin and dutasteride are medications combined for the treatment of benign prostatic hyperplasia (BPH) in men. Tamsulosin is an alpha-1 adrenergic antagonist that relaxes the muscles in the prostate and bladder neck, making it easier to urinate. Dutasteride is a 5-alpha reductase inhibitor that reduces the size of the prostate gland. The combination is used to improve urinary symptoms and is approved and widely used clinically.
Pharmacokinetic parameter estimates for adult male subjects with BPH, typical population parameters for tamsulosin and dutasteride combination therapy after oral administration.