Fluorouracil (5-FU) is an antimetabolite chemotherapeutic
agent that inhibits thymidylate synthase, disrupting DNA synthesis
and repair, thereby exerting cytotoxic effects on rapidly dividing
cancer cells.
Fluorouracil is widely used against gastrointestinal, breast,
head and neck, and skin cancers, particularly effective for
colorectal cancer.
PK of fluorouracil in humans administered IV. Modeled as
1-compartment model with Cl=84.6 l/h, Vd=18.66l, dose=250 mg from
[1].
References:
[1] Phillips, Thomas A., et al. "Pharmacokinetics of oral and
intravenous fluorouracil in humans." Journal
of pharmaceutical sciences 69.12
(1980): 1428-1431.
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