.Pharmacolibrary.Drugs.N_NervousSystem.N02B_OtherAnalgesicsAndAntipyretics.N02BE01_Paracetamol.Paracetamol_metabolites

In healthy adults, paracetamol is rapidly absorbed and widely distributed with a volume of distribution approximating total body water, undergoing extensive hepatic metabolism primarily via glucuronidation and sulfation pathways, with a minor fraction oxidized by cytochrome P450 enzymes to form the toxic reactive metabolite NAPQI, which is subsequently detoxified by glutathione conjugation.

There are other metabolites observed in animal experiments, but not found in humans, thus not present in model implementation.