.Pharmacolibrary.Drugs.P_AntiparasiticProductsInsecticidesAndRepellents.P01B_Antimalarials.P01BF07_ArtemisininAndPiperaquin.ArtemisininAndPiperaquin

Information

Artemisinin and piperaquine is a fixed-dose artemisinin-based combination therapy (ACT) used primarily for the treatment of uncomplicated Plasmodium falciparum malaria. Artemisinin acts rapidly to reduce parasite burden, while piperaquine provides a longer duration of action to clear remaining parasites. This combination is approved and widely used as a first-line therapy in several malaria-endemic countries.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adults, both sexes, after oral administration of fixed-dose combination tablets.

References

1. Reuter, SE, et al., & Pace, S (2015). Effect of food on the pharmacokinetics of piperaquine and dihydroartemisinin. Clinical drug investigation 35(9) 559–567. DOI:10.1007/s40261-015-0312-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26293519

2. Tarning, J, et al., & Lindegardh, N (2012). Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria. Clinical pharmacology and therapeutics 91(3) 497–505. DOI:10.1038/clpt.2011.254 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22258469

3. Tarning, J, et al., & Lindegardh, N (2012). Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated malaria. Antimicrobial agents and chemotherapy 56(4) 1997–2007. DOI:10.1128/AAC.05756-11 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22252822

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)