.Pharmacolibrary.Drugs.R_RespiratorySystem.R01A_DecongestantsAndOtherNasalPreparationsForTopical.R01AA14_Epinephrine.Epinephrine .Pharmacolibrary.Drugs.R_RespiratorySystem.R01A_DecongestantsAndOtherNasalPreparationsForTopical.R01AA14_Epinephrine.Epinephrine| name: | Epinephrine | |
| ATC code: | R01AA14 | |
| route: | intranasal | |
| compartments: | 1 | |
| dosage: | 2 | mg |
| volume of distribution: | 0.3 | L |
| clearance: | 1300 | mL/min |
| other parameters in model implementation | ||
Epinephrine (also known as adrenaline) is a naturally occurring catecholamine hormone and neurotransmitter used primarily in emergency medicine. It is indicated for the treatment of severe allergic reactions (anaphylaxis), cardiac arrest, and as a vasoconstrictor in shock. It is approved and widely used today in various clinical settings.
Pharmacokinetic parameters estimated for adult healthy individuals. No direct publication was found for intranasal/ATC R01AA14-specific administration; values are extrapolated from general human PK and alternative routes (intramuscular/intravenous) as reference.
Yoo, H, et al., & Jusko, WJ (2015). Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects. European journal of clinical pharmacology 71(10) 1197–1207. DOI:10.1007/s00228-015-1913-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26233335