When a drug distributes into peripheral tissues, a
twocompartment model often better captures the observed
pharmacokinetics. Diagram view illustrates this setup:
administration and elimination are linked to the central
compartment, while the peripheral compartment exchanges drug with
the central compartment via first-order transfer, mimicking tissue
diffusion.
References:
Fleishaker, J C and R B Smith (1987-12). “Compartmental model
analysis in pharmacokinetics”. en. In: J. Clin. Pharmacol. 27.12,
pp. 922–926. ISSN: 0091-2700,1552-4604. DOI:
10.1002/j.1552-4604.1987.tb05591.x. URL:
http://dx.doi.org/10.1002/j.1552-4604.1987.tb05591.x.
.Pharmacolibrary.Examples.PKTwoCompartmentModel