.Pharmacolibrary.Interfaces.PartialBloodTissueCompartment

The Partial Tissue compartments has two FlowPorts and one BloodTissueConcentrationPort connectors. It stores a mass of drug which is diluted in constant volume of blood/plamsa. It evaluates drug concentration, calculates mixing of inflow and contained blood/plasma of different drug concentrations and calculates change in drug amount due to transfer via the BloodTissueConcentrationPort.

If it is connected to other compartments via the BloodTissueConcentrationPort, there should be a transfer component inbetween.

C = M/V

CB = C/kTB

freeTissueConc = fu*C

freeBloodConc = fu*C/kTB

V - total distribution volume

C0 - drug initial concentration in tissue

kTB - tissue-blood concentration ratio

fu - fraction unbound