indirect zero order stimulation effect model
ZeroOrderStimulationEffect
indirect zero order stimulation effect model. Effect E is
calculated using an differential equation
Emax * c
E' = kIn*(1 +
----------) -
kOut*E
c + c50
where c is the free concentration (either tissue or blood/plasma,
depending on the switch) at the BloodTissueConcentrationPort
connector.
Parameters
Emax - maximal
effect
c50
- concentration producing
50% of maximum stimulation
kIn - zero-order response
production constant
kOut - first-order response loss
rate constant
Boolean cBSwitch - false: use tissue free conc, true: use blood
free conc
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.Pharmacolibrary.Pharmacodynamic.ZeroOrderStimulationEffect