.Pharmacolibrary.Pharmacogenomics.PGx.phScaleCL

Information

phScaleCL(ph, a1, a2) returns the clearance‐scaling factor associated with the combined genotype a1/a2 and phenotype ph by:

1. Calling phStatus(ph,a1,a2) to get a MetabolizerStatus.
2. Indexing the ph.CLscale vector at that status (converted to an integer).

Inputs:

ph – A Phenotype record with fields: poor, intermediate, rapid, and a CLscale array of length six.

a1, a2 – Star‐allele strings.

Output:

f – Real factor (e.g. 0.85) to multiply the nominal clearance.

Interface

function phScaleCL
  input PGx.Phenotype ph;
  input String a1;
  input String a2;
  output Real f;
end phScaleCL;