.Pharmacolibrary.Examples.PKPD_integration.PKPD_HemodynamicsMeurs_flatNorm

Information

CAUTION: This model depends on Physiolibrary 3.0 and Chemical[3]. Please download and open it before simulating this model example.

Parameters of PD influence on HR and compliance of left ventricle are for ilustrative estimates. Other parameters are from referred articles. Model of hemodynamics of cardiovascular system [1] and PKPD model of digoxin effect [2]. 

[1] W. van Meurs, Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology, McGraw-Hill Professional, 2011.

[2] Hornestam, B., Jerling, M., Karlsson, M.O. et al. Intravenously administered digoxin in patients with acute atrial fibrillation: a population pharmacokinetic/pharmacodynamic analysis based on the Digitalis in Acute Atrial Fibrillation trial. Eur J Clin Pharmacol 58, 747–755 (2003). doi.org/10.1007/s00228-002-0553-3

[3] https://www.physiolibrary.org

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